If you truly wish to erase them (versus minimize them), it might take a combination of modalities. But I think that your primary tool is laser--not the old Fraxel ones that have now been around for ages--but one of the newer ones that's more powerful and precise.

You may want to ask Anya about her opinion of using Fibroblast treatment to address this - it seems to have greatly helped the lines/crepiness around her eyes, and I believe the same modality may be useful for lines around the mouth.

It's an old technology repurposed (and renamed) - it's essentially electrofulguration (creating an arc of electricity to superficially and precisely burn the upper layers of skin), used in a "fractionated" pattern (a la fractionated CO2 lasers) used to selectively destroy tissue to stimulate a healing response that tightens skin and encourages collagen production. It seems to be an inexpensive, relatively safe, and potentially effective option, especially for fairer skin types.

Some seem to benefit from microneedling in this area (same concept of selective damage to stimulate a healing response), as well as medium-depth peels (TCA, etc.) and certain laser treatments (fracitonated CO2, etc.).

I've not seen much compelling evidence for PRP, but I'm sure many have anecdotally benefited from it. If money is not an issue, it may be worth pursuing since it's relatively low risk (though a story has been recently running claiming that sloppy doctors exposed patients to HIV via PRP), but personally I'd go for a modality that has a higher chance of making a positive difference.

Thank you JB01 and Greg for your interesting responses...

The doc I went to, also suggested little HA to be injected into the lines with a microneedle...
But, sincerely I am so scared of making damage with the permanent filler in place, to get an unexcpeted reaction, as I am also somehow reactive and have some light problems with immunity.

Maybe PRP associated with microneedling, could be interesting?
or very light laser...
I'll look into it and what you suggested.
Have a nice day,

You can think about it this way - you can either fill them from the inside (filler) or try to get your body to fill them in from the "outside" (I.e. plump the collagen in the dermis via chemicals, dermbrasion or laser)

chemical peeling, dermbrasion and lasers don't create granulomas. Dermbrasion isn't really any better or worse than chemicals or lasers... it's just three different ways of doing controlled damage to the skin in order to create (hopefully smoother/less wrinkled) regrowth. they all have the potential for poor healing with accompanying possibility of hypo or hyper pigmentation. Microneedling does the same, but it's just less invasive. With PRP, I think a good amount of the benefit is caused by the microneedling itself rather than the PRP

I had erbium laser under my eyes to address "bunching" when I smile and it did help. That did require hiding out for a week though. (went out behind sunglasses, but the area was red, gloppy, etc). After that I was able to cover the redness with makeup

If you are risk averse then a series of mild chemical peels might be the place to start. But as with any of the things we discuss here... less invasive = less results.

Thank you Robin for your interesting comment !