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Offline violeta  
#1 Posted : Monday, October 08, 2012 7:29:04 AM(UTC)
Rank: Advanced Member

Joined: 8/11/2008(UTC)
Posts: 1,217
Location: northeast
It's main ingredient is an extract of the dried root of Astragalus, an herbal antioxidant which is quite potent on its own. I've taken Astragulus before but not continuously. I have Asian friends who say some of their family takes it for years or they cook with the actual herb, especially in soup.
TA-65 is supposedly more potent and lengthens the telomeres of cells, which shorten as we age. There are docs who are concerned this may possibly lead to cancer, if cells are allowed to replicate non stop. I'm not sure if this is the case with TA-65, or if it depends on how long it's taken or the dosage. Some antiaging docs in NY believe in it, and dispense it to patients. It's also available online, although I don't know what would be the most reputable source. I've read some docs who've taken it said they found it improved their eyesight and hair, and also skin texture over time. There doesn't seem to be too many long term studies on it though. Perhaps taking Astragalus (or cooking with it) only can help since it's a potent antioxidant and it's been used in Asian countries for many years already. But this pill does seem interesting, if it will actually work to reverse some aging inside and maybe some on the outside.

http://www.prweb.com/rel...lomeres/prweb9488264.htm
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Offline mich  
#2 Posted : Monday, October 08, 2012 10:48:26 AM(UTC)
Rank: Advanced Member

Joined: 6/11/2008(UTC)
Posts: 1,079
I am confused about telomeres does it include skin cells?, does that mean that skin cells when made to turnover quickly via peels ect. will in the end actually speed up aging of the face?
Offline violeta  
#3 Posted : Monday, October 08, 2012 11:29:43 AM(UTC)
Rank: Advanced Member

Joined: 8/11/2008(UTC)
Posts: 1,217
Location: northeast
mich wrote:
I am confused about telomeres does it include skin cells?, does that mean that skin cells when made to turnover quickly via peels ect. will in the end actually speed up aging of the face?


Skin cells turn over more quickly when using retinoids like Retin-A or Tazorac, and I know it's been studied for decades, and people actually age more slowly when using it for years. I've read a few studies where they say they don't actually know the exact mechanism by which tretinoin, (Retin-A) actually makes skin cells shed faster, but it's been proven to create new collagen cells. Dr. Kligman supposedly discovered it in the late 60s, and it's been used for decades not just for acne but 'off label' for antiaging. I've used Retin-A for several years and Tazaroc and think it's why I don't have crows feet or forehead wrinkles yet (late 30s, yet I have cousins younger with more wrinkles) and overall clear skin most of the time. I don't know if Retin-a lengthens telomeres.

But the pill TA-65 with astragulus root is supposed to do that, which means all cells including skin; so telomeres will not shorten so soon and aging will be delayed. Some docs claim it can actually reverse some aging signs but there are not enough long term studies. The problem is what if in the long run it can cause cells to grow out of control which is also the controversy with using growth hormones..leading to possible cancer. So I don't know if this pill is good or if maybe it's ok short term or maybe long term they will find it doesn't cause cancer and may indeed delay the aging process. Resveratrol is supposed to do the same thing but most pills are not absorbed well or bioactive.

Quote from another article below:
"Florence Comite, a Manhattan endocrinologist and age-management specialist who dispenses TA-65, doesn't believe there's a connection. Within six months of taking TA-65, she stopped using her reading glasses; after two years, she thinks her skin is smoother. "I've seen it extend the length of patients' DNA," she says, "but there are no long-term studies." In one small study, TA-65 appeared to rewind aging in mice — regrowing their hair, thickening their skin — and patients have reported similar results. "As research accumulates, I see it becoming more accessible and mainstream," predicts Comite."


http://www.harpersbazaar...the-new-youth-pills-1011

Offline Sarah W  
#4 Posted : Monday, October 08, 2012 12:44:35 PM(UTC)
Rank: Advanced Member

Joined: 6/4/2008(UTC)
Posts: 8,137
Woman
I always worry if there are insufficient double blind trials. It is a crap shoot, really.JMO

Plus I am always a little skeptical when the person making the claims is the same person who has a financial interest in the company

However it is very seductive when it claims to 'rewind aging' though,lol
Offline violeta  
#5 Posted : Monday, October 08, 2012 1:12:49 PM(UTC)
Rank: Advanced Member

Joined: 8/11/2008(UTC)
Posts: 1,217
Location: northeast
Sarah W wrote:
I always worry if there are insufficient double blind trials. It is a crap shoot, really.JMO

Plus I am always a little skeptical when the person making the claims is the same person who has a financial interest in the company

However it is very seductive when it claims to 'rewind aging' though,lol


I agree with you, plus it's very expensive. But I think there may be some benefits to the pill if it has Astragalus root, since this herb has been used for thousands of years in Chinese medicine fatigue, lung infections, and other diseases. There are hundreds of studies on it listed on Pubmed, and Medline, which show it's anti-inflammatory. Since one main cause of aging is inflammation, I think it may good idea to take Astragalus root itself which is much cheaper. Question is how much is enough to produce an age reversing response. Anyway, it has many healing properties and stimulates the immune system, which is always good. I wonder if the TA 65 is just high doses of Astragalus and they have a patent on the pill, to make it super expensive. Maybe similar effects can be achieved by taking Astragalus root pills daily, which can be found in health food stores, and there are pure organic versions.
Offline Sarah W  
#6 Posted : Monday, October 08, 2012 4:21:24 PM(UTC)
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Joined: 6/4/2008(UTC)
Posts: 8,137
Woman
Astralagus is not without it's side effects so you need to be careful for example if you have autoimmune problems and are taking other medications
Offline violeta  
#7 Posted : Monday, October 08, 2012 5:00:05 PM(UTC)
Rank: Advanced Member

Joined: 8/11/2008(UTC)
Posts: 1,217
Location: northeast
Sarah W wrote:
Astralagus is not without it's side effects so you need to be careful for example if you have autoimmune problems and are taking other medications

Yes, I read about that. I think everyone needs to read on potential side effects with any supplement whether a vitamin or herbal, however natural they may be.., there are always going to be contraindications for certain people with specific conditions or those taking certain meds.
Offline Geijutsu  
#8 Posted : Monday, October 08, 2012 7:05:11 PM(UTC)
Rank: Advanced Member

Joined: 4/28/2012(UTC)
Posts: 1,458
I've been interested in it since almost 2 years now, but still not sure to take it, there are still some concerns regarding cancer.
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Offline Bugjune  
#9 Posted : Tuesday, October 09, 2012 2:41:11 PM(UTC)
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Joined: 6/29/2009(UTC)
Posts: 4,410
Woman
Location: The leaf I am sitting on
I had seen a "Dr. Oz" segment in which he talked about astragalus supplements. Also known as the "locoweed" plant, it's the roots that are used in teas, soups, powder form, pills, etc.

It's primarily used to boost the immune system - which is why people are taking it if they have cancer, have a heart condition or even want to prevent a viral infection. If a person is on corticosteroids, they should probably NOT take this root, as it would interfere with their immune system response.

The fact that astragalus has some antioxidant properties has everyone jumping on the anti-aging bandwagon. And for antioxidants, well there's always healthy eating: berries, kale, spinach, cruciferous foods! Voila! You'll add another 5 years to your life.

I've also read that taking astragalus can block the bowels. And having endured a bout of that about 2 mos ago ... um, NO THANKS!

Edit: here's an article that talks about the TA-65 pill and the controversy surrounding it:
http://tinyurl.com/3hkgqna

I'm glad to read that healthy eating and exercise are probably about as effective on our telomeres!
I bug you.

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